SLIT1 Antibody

• Background:

  Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity) . SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.

• NCBI Gene ID:

  6585

• Swiss Prot:

  O75093

• Accession Number:

  O75093

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This SLIT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-113 amino acids from the N-terminal region of human SLIT1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  168 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SLIT1

• NCBI Official Name:

  Slit homolog 1 protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Marlow, R., et al. Cancer Res. 68 (19) :7819-7827 (2008)

• Background Reference 02:

  Hussain, S.A., et al. J. Biol. Chem. 281 (51) :39693-39698 (2006)

• Background Reference 03:

  Lin, L., et al. Stem Cells 24 (11) :2504-2513 (2006)

• Background Reference 04:

  Lim, J., et al. Cell 125 (4) :801-814 (2006)

• Other Product Names:

  Slit homolog 1 protein, Slit-1, Multiple epidermal growth factor-like domains protein 4, Multiple EGF-like domains protein 4, SLIT1, KIAA0813, MEGF4, SLIL1

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid