SSX4 Antibody

• Background:

  The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t (X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4B, represents the more centromeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene.

• NCBI Gene ID:

  5483136759

• Swiss Prot:

  O60224

• Accession Number:

  O60224

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SSX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-91 amino acids from the Central region of human SSX4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  22 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SSX4

• NCBI Official Name:

  Protein SSX4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ayyoub, M., et al. J. Immunol. 174 (8) :5092-5099 (2005)

• Background Reference 02:

  Ross, M.T., et al. Nature 434 (7031) :325-337 (2005)

• Background Reference 03:

  Gure, A.O., et al. Int. J. Cancer 101 (5) :448-453 (2002)

• Background Reference 04:

  Brodin, B., et al. Gene 268 (1-2), 173-182 (2001) :

• Other Product Names:

  Protein SSX4, Cancer/testis antigen 54, CT54, SSX4, SSX4A

• Tested Applications:

  WB

• Physical Properties:

  Liquid