HEMGN Antibody

• Background:

  HEMGN regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) .

• NCBI Gene ID:

  55363

• Swiss Prot:

  Q9BXL5

• Accession Number:

  Q9BXL5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This HEMGN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 420-449 amino acids from the C-terminal region of human HEMGN.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  55 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  HEMGN

• NCBI Official Name:

  Hemogen

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ding, Y.L., et al. J. Cell. Biochem. 110 (4) :866-874 (2010)

• Background Reference 02:

  Moreno, L.M., et al. Hum. Mol. Genet. 18 (24) :4879-4896 (2009)

• Background Reference 03:

  Lowe, J.K., et al. PLoS Genet. (2), E1000365 (2009) :

• Background Reference 04:

  Li, C.Y., et al. Biochim. Biophys. Acta 1779 (10) :606-615 (2008)

• Other Product Names:

  Hemogen, Erythroid differentiation-associated gene protein, EDAG-1, Hemopoietic gene protein, Negative differentiation regulator protein, HEMGN, EDAG, NDR

• Tested Applications:

  WB

• Protein ID:

  74752432

• Physical Properties:

  Liquid