KCNV2 Antibody

• Background:

  Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues.

• NCBI Gene ID:

  169522

• Swiss Prot:

  Q8TDN2

• Accession Number:

  Q8TDN2

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This KCNV2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 478-507 amino acids from the C-terminal region of human KCNV2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  62 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  KCNV2

• NCBI Official Name:

  Potassium voltage-gated channel subfamily V member 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Robson, A.G., et al. Retina (Philadelphia, Pa.) 30 (1) :51-62 (2010)

• Background Reference 02:

  Ben Salah, S., et al. Am. J. Ophthalmol. 145 (6) :1099-1106 (2008)

• Background Reference 03:

  Wissinger, B., et al. Invest. Ophthalmol. Vis. Sci. 49 (2) :751-757 (2008)

• Background Reference 04:

  Thiagalingam, S., et al. Ophthalmic Genet. 28 (3) :135-142 (2007)

• Other Product Names:

  Potassium voltage-gated channel subfamily V member 2, Voltage-gated potassium channel subunit Kv82, KCNV2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  26006804

• Physical Properties:

  Liquid