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NAE1 Antibody

CAT: 0223-56-829Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-829Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
8883
Swiss Prot
Q13564
Accession Number
Q13564
Host
Rabbit
Reactivity
Human
Immunogen
This NAE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the Central region of human NAE1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
60 kDa
Fragment
Rabbit Ig
Symbol
NAE1
NCBI Official Name
NEDD8-activating enzyme E1 regulatory subunit
NCBI Organism
Homo sapiens
Background Reference 01
Jung, A.C., et al. Int. J. Cancer 126 (8) :1882-1894 (2010)
Background Reference 02
Park, Y., et al. Biochem. Biophys. Res. Commun. 374 (2) :294-298 (2008)
Background Reference 03
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Background Reference 04
Li, T., et al. Arch. Biochem. Biophys. 453 (1) :70-74 (2006)
Other Product Names
NEDD8-activating enzyme E1 regulatory subunit, Amyloid beta precursor protein-binding protein 1, 59 kDa, APP-BP1, Amyloid protein-binding protein 1, Proto-oncogene protein 1, NAE1, APPBP1
Tested Applications
WB, IHC-P
Protein ID
50400302
Physical Properties
Liquid

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