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AR Antibody

CAT: 0223-56-824Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-824Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease) . Mutations in this gene are also associated with complete androgen insensitivity (CAIS) . Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq].
NCBI Gene ID
367
Swiss Prot
P10275
Accession Number
P10275
Host
Rabbit
Reactivity
Human
Immunogen
This AR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-309 amino acids from the Central region of human AR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
99 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
AR
NCBI Official Name
Androgen receptor
NCBI Organism
Homo sapiens
Background Reference 01
Shu, S.K., et al. J. Biol. Chem. 285 (43) :33045-33053 (2010)
Background Reference 02
Nedelsky, N.B., et al. Neuron 67 (6) :936-952 (2010)
Background Reference 03
Panda, B., et al. Gynecol. Endocrinol. (2010) In press :
Background Reference 04
Schneider, G., et al. AmGeriatr Psychiatry (2010) In press :
Other Product Names
Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4
Tested Applications
WB
Protein ID
113830
Physical Properties
Liquid

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