CTPS2 Antibody

• Background:

  The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.

• NCBI Gene ID:

  56474

• Swiss Prot:

  Q9NRF8

• Accession Number:

  Q9NRF8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 450-479 amino acids from the C-terminal region of human CTPS2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  66 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CTPS2

• NCBI Official Name:

  CTP synthase 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kassel, K.M., et al. J. Biol. Chem. 285 (44) :33727-33736 (2010)

• Background Reference 02:

  Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

• Background Reference 03:

  Han, G.S., et al. J. Biol. Chem. 280 (46) :38328-38336 (2005)

• Background Reference 04:

  Ross, M.T., et al. Nature 434 (7031) :325-337 (2005)

• Other Product Names:

  CTP synthase 2, CTP synthetase 2, UTP--ammonia ligase 2, CTPS2

• Tested Applications:

  WB

• Protein ID:

  74752919

• Physical Properties:

  Liquid