CTPS2 Antibody

CAT: 0223-56-805Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-805Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.
NCBI Gene ID
56474
Swiss Prot
Q9NRF8
Accession Number
Q9NRF8
Host
Rabbit
Reactivity
Human
Immunogen
This CTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 450-479 amino acids from the C-terminal region of human CTPS2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
66 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CTPS2
NCBI Official Name
CTP synthase 2
NCBI Organism
Homo sapiens
Background Reference 01
Kassel, K.M., et al. J. Biol. Chem. 285 (44) :33727-33736 (2010)
Background Reference 02
Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)
Background Reference 03
Han, G.S., et al. J. Biol. Chem. 280 (46) :38328-38336 (2005)
Background Reference 04
Ross, M.T., et al. Nature 434 (7031) :325-337 (2005)
Other Product Names
CTP synthase 2, CTP synthetase 2, UTP--ammonia ligase 2, CTPS2
Tested Applications
WB
Protein ID
74752919
Physical Properties
Liquid

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