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MBTPS2 Antibody

CAT: 0223-56-769Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-769Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome) ; IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.
NCBI Gene ID
51360
Swiss Prot
O43462
Accession Number
O43462
Host
Rabbit
Reactivity
Human
Immunogen
This MBTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human MBTPS2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
57 kDa
Fragment
Rabbit Ig
Symbol
MBTPS2
NCBI Official Name
Membrane-bound transcription factor site-2 protease
NCBI Organism
Homo sapiens
Background Reference 01
Ming, A., et al. Pediatr Dermatol 26 (4) :427-431 (2009)
Background Reference 02
Oeffner, F., et al. Am. J. Hum. Genet. 84 (4) :459-467 (2009)
Background Reference 03
Lu, Y., et al. J. Lipid Res. 49 (12) :2582-2589 (2008)
Background Reference 04
Shen, J., et al. J. Biol. Chem. 279 (41) :43046-43051 (2004)
Other Product Names
Membrane-bound transcription factor site-2 protease, Endopeptidase S2P, Sterol regulatory element-binding proteins intramembrane protease, SREBPs intramembrane protease, MBTPS2, S2P
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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