MBTPS2 Antibody

• Background:

  This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome) ; IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.

• NCBI Gene ID:

  51360

• Swiss Prot:

  O43462

• Accession Number:

  O43462

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MBTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human MBTPS2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  57 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MBTPS2

• NCBI Official Name:

  Membrane-bound transcription factor site-2 protease

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ming, A., et al. Pediatr Dermatol 26 (4) :427-431 (2009)

• Background Reference 02:

  Oeffner, F., et al. Am. J. Hum. Genet. 84 (4) :459-467 (2009)

• Background Reference 03:

  Lu, Y., et al. J. Lipid Res. 49 (12) :2582-2589 (2008)

• Background Reference 04:

  Shen, J., et al. J. Biol. Chem. 279 (41) :43046-43051 (2004)

• Other Product Names:

  Membrane-bound transcription factor site-2 protease, Endopeptidase S2P, Sterol regulatory element-binding proteins intramembrane protease, SREBPs intramembrane protease, MBTPS2, S2P

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid