PPARA Antibody

• Background :

  Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.

• NCBI Gene ID :

  5465

• Swiss Prot :

  Q07869

• Accession Number :

  Q07869

• Host :

  Rabbit

• Reactivity :

  Mouse

• Immunogen :

  This PPARA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-181 amino acids from the Central region of human PPARA.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Obesity

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Rat, Xenopus

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  52 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  PPARA

• NCBI Official Name :

  Peroxisome proliferator-activated receptor alpha

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Jablonski, K.A., et al. Diabetes 59 (10) :2672-2681 (2010)

• Background Reference 02 :

  Hu, M., et al. Pharmacogenet. Genomics 20 (10) :634-637 (2010)

• Background Reference 03 :

  Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :

• Background Reference 04 :

  Eynon, N., et al. Mitochondrion (2010) In press :

• Other Product Names :

  Peroxisome proliferator-activated receptor alpha, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1, PPARA, NR1C1, PPAR

• Tested Applications :

  WB, Flow

• Protein ID :

  3041727

• Physical Properties :

  Liquid