PPARD Antibody

CAT: 0223-27-732Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-27-732Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PPARD is a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR delta and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.
NCBI Gene ID
5467
Swiss Prot
Q03181
Accession Number
NP_006229
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PPARD.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PPARD antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
49 kDa
Applications Notes
PPARD antibody can be used for detection of PPARD by ELISA at 1:1562500. PPARD antibody can be used for detection of PPARD by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
PPARD
NCBI Official Name
Peroxisome proliferator-activated receptor delta
NCBI Organism
Homo sapiens
Background Reference 01
Barish, G.D., et al., (2006) J. Clin. Invest. 116 (3), 590-597.
Other Product Names
PPARD, FAAR, NUC1, NUCI, NR1C2, NUCII, PPARB
Tested Applications
ELISA, WB
Protein ID
5453940
Physical Properties
Liquid

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