PPARD Antibody

• Background :

  This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.

• NCBI Gene ID :

  5467

• Swiss Prot :

  Q03181

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 102-361 of human PPARD (NP_803184.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Apoptosis, Cancer, Cell Cycle, Obesity, Signal Transduction, Transcription

• Purification :

  Affinity purification

• Positive Control :

  BT-474

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 56kDa

• Fragment :

  IgG

• Symbol :

  PPARD

• Positive Control 2 :

  Mouse heart

• NCBI Official Name :

  Peroxisome proliferator-activated receptor delta

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  PPARD, FAAR, NUC1, NUCI, NR1C2, NUCII, PPARB

• Tested Applications :

  WB, IF

• Physical Properties :

  Liquid