GCDH Antibody

• Background:

  The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO (2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.

• NCBI Gene ID:

  2639

• Swiss Prot:

  Q92947

• Accession Number:

  Q92947

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GCDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-365 amino acids from the C-terminal region of human GCDH.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Monkey

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GCDH

• NCBI Official Name:

  Glutaryl-CoA dehydrogenase, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Park, J.D., et al. J. Korean Med. Sci. 25 (6) :957-960 (2010)

• Background Reference 03:

  Strauss, K.A., et al. Brain 133 (PT 1), 76-92 (2010) :

• Background Reference 04:

  Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

• Other Product Names:

  Glutaryl-CoA dehydrogenase, mitochondrial, GCD, GCDH

• Tested Applications:

  WB, IHC-P

• Protein ID:

  2492631

• Physical Properties:

  Liquid