PVRL3 Antibody

• Background:

  Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559) . Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090) -catenin (see MIM 116805) system in epithelial cells.

• NCBI Gene ID:

  25945

• Swiss Prot:

  Q9NQS3

• Accession Number:

  Q9NQS3

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PVRL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 507-536 amino acids from the C-terminal region of human PVRL3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  61 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PVRL3

• NCBI Official Name:

  Nectin-3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

• Background Reference 03:

  Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

• Background Reference 04:

  Yu, X., et al. Nat. Immunol. 10 (1) :48-57 (2009)

• Other Product Names:

  Nectin-3, CDw113, Poliovirus receptor-related protein 3, CD113, PVRL3, PRR3

• Tested Applications:

  WB

• Protein ID:

  74762752

• Physical Properties:

  Liquid