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LOXL3 Antibody

CAT: 0223-56-683Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-683Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined.
NCBI Gene ID
84695
Swiss Prot
P58215
Accession Number
P58215
Host
Rabbit
Reactivity
Human
Immunogen
This LOXL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 715-744 amino acids from the C-terminal region of human LOXL3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
83 kDa
Fragment
Rabbit Ig
Symbol
LOXL3
NCBI Official Name
Lysyl oxidase homolog 3
NCBI Organism
Homo sapiens
Background Reference 01
Kim, Y., et al. Oncol. Rep. 22 (4) :799-804 (2009)
Background Reference 02
Sebban, S., et al. Virchows Arch. 454 (1) :71-79 (2009)
Background Reference 03
Akagawa, H., et al. Hum. Genet. 121 (3-4), 377-387 (2007) :
Background Reference 04
Lee, J.E., et al. J. Biol. Chem. 281 (49) :37282-37290 (2006)
Other Product Names
Lysyl oxidase homolog 3, 143-, Lysyl oxidase-like protein 3, LOXL3, LOXL
Tested Applications
WB, IHC-P
Protein ID
14916616
Physical Properties
Liquid

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