ABRA Antibody

• Background:

  ABRA acts as an activator of serum response factor (SRF) -dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity) .

• NCBI Gene ID:

  137735

• Swiss Prot:

  Q8N0Z2

• Accession Number:

  Q8N0Z2

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ABRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-304 amino acids from the C-terminal region of human ABRA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  43 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ABRA

• NCBI Official Name:

  Actin-binding Rho-activating protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lamon, S., et al. J. Physiol. (Lond.) 587 (PT 8), 1795-1803 (2009) Kuwahara, K., et al. J. Clin. Invest. 117 (5) :1324-1334 (2007) Kuwahara, K., et al. Mol. Cell. Biol. 25 (8) :3173-3181 (2005) Arai, A., et al. J. Biol. Chem. 277 (27) :24453-24459 (2002) Simpson, J.C., et al. EMBO Rep. 1 (3) :287-292 (2000)

• Other Product Names:

  Actin-binding Rho-activating protein, Striated muscle activator of Rho-dependent signaling, STARS, ABRA {ECO:0000312|EMBL:AAI051061}

• Tested Applications:

  WB, IHC-P

• Protein ID:

  74728477

• Physical Properties:

  Liquid