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MUL1 Antibody

CAT: 0223-56-663Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-663Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
NCBI Gene ID
79594
Swiss Prot
Q969V5
Accession Number
Q969V5
Host
Rabbit
Reactivity
Human
Immunogen
This MUL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-301 amino acids from the C-terminal region of human MUL1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
40 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MUL1
NCBI Official Name
Mitochondrial ubiquitin ligase activator of NFKB 1
NCBI Organism
Homo sapiens
Background Reference 01
Laure, L., et al. FEBS J. 277 (20) :4322-4337 (2010)
Background Reference 02
Braschi, E., et al. EMBO Rep. 10 (7) :748-754 (2009)
Background Reference 03
Venkatesan, K., et al. Nat. Methods 6 (1) :83-90 (2009)
Background Reference 04
Zhang, B., et al. Cell Res. 18 (9) :900-910 (2008)
Other Product Names
Mitochondrial ubiquitin ligase activator of NFKB 1, 632-, E3 SUMO-protein ligase MUL1, E3 ubiquitin-protein ligase MUL1, Growth inhibition and death E3 ligase, Mitochondrial-anchored protein ligase, MAPL, Putative NF-kappa-B-activating protein 266, RING finger protein 218, MUL1, C1orf166, GIDE, MAPL, MULAN, RNF218
Tested Applications
WB
Protein ID
74760689
Physical Properties
Liquid

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