SULF2 Antibody

• Background :

  Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]) .

• NCBI Gene ID :

  55959

• Swiss Prot :

  Q8IWU5

• Accession Number :

  Q8IWU5

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This SULF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 824-852 amino acids from the C-terminal region of human SULF2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Obesity, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  100 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  SULF2

• NCBI Official Name :

  Extracellular sulfatase Sulf-2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Lai, J.P., et al. Hepatology 52 (5) :1680-1689 (2010) Ellinor, P.T., et al. Nat. Genet. 42 (3) :240-244 (2010) Lemjabbar-Alaoui, H., et al. Oncogene 29 (5) :635-646 (2010) Tang, R., et al. J. Biol. Chem. 284 (32) :21505-21514 (2009) Chau, B.N., et al. Cancer Res. 69 (4) :1368-1374 (2009)

• Other Product Names :

  Extracellular sulfatase Sulf-2, hSulf-2, 316-, SULF2, KIAA1247

• Tested Applications :

  WB

• Protein ID :

  33112446

• Physical Properties :

  Liquid