SHANK2 Antibody

• Background :

  This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD) . Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined. [provided by RefSeq].

• NCBI Gene ID :

  22941

• Swiss Prot :

  Q9UPX8

• Accession Number :

  Q9UPX8

• Host :

  Rabbit

• Reactivity :

  Mouse

• Immunogen :

  This SHANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 879-908 amino acids from the Central region of human SHANK2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  159 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  SHANK2

• NCBI Official Name :

  SH3 and multiple ankyrin repeat domains protein 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Pinto, D., et al. Nature 466 (7304) :368-372 (2010)

• Background Reference 02 :

  Berkel, S., et al. Nat. Genet. 42 (6) :489-491 (2010)

• Background Reference 03 :

  Lee, J.S., et al. J. Biol. Chem. 285 (11) :8104-8113 (2010)

• Background Reference 04 :

  Wu, C., et al. Proteomics 7 (11) :1775-1785 (2007)

• Other Product Names :

  SH3 and multiple ankyrin repeat domains protein 2, Shank2, Cortactin-binding protein 1, CortBP1, Proline-rich synapse-associated protein 1, SHANK2, CORTBP1, KIAA1022, PROSAP1

• Tested Applications :

  WB

• Protein ID :

  254763402

• Physical Properties :

  Liquid