SHANK2 Antibody

CAT: 0223-56-643Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-643Size:400 µL
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Background
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD) . Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined. [provided by RefSeq].
NCBI Gene ID
22941
Swiss Prot
Q9UPX8
Accession Number
Q9UPX8
Host
Rabbit
Reactivity
Mouse
Immunogen
This SHANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 879-908 amino acids from the Central region of human SHANK2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
159 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SHANK2
NCBI Official Name
SH3 and multiple ankyrin repeat domains protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Pinto, D., et al. Nature 466 (7304) :368-372 (2010)
Background Reference 02
Berkel, S., et al. Nat. Genet. 42 (6) :489-491 (2010)
Background Reference 03
Lee, J.S., et al. J. Biol. Chem. 285 (11) :8104-8113 (2010)
Background Reference 04
Wu, C., et al. Proteomics 7 (11) :1775-1785 (2007)
Other Product Names
SH3 and multiple ankyrin repeat domains protein 2, Shank2, Cortactin-binding protein 1, CortBP1, Proline-rich synapse-associated protein 1, SHANK2, CORTBP1, KIAA1022, PROSAP1
Tested Applications
WB
Protein ID
254763402
Physical Properties
Liquid

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