MAT1A Antibody

• Background:

  This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.

• NCBI Gene ID:

  4143

• Swiss Prot:

  Q00266

• Accession Number:

  Q00266

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MAT1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-136 amino acids from the N-terminal region of human MAT1A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat, Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  44 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MAT1A

• NCBI Official Name:

  S-adenosylmethionine synthase isoform type-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Wu, S.M., et al. Cell. Mol. Life Sci. 67 (11) :1831-1843 (2010)

• Background Reference 03:

  Lai, C.Q., et al. Am. J. Clin. Nutr. 91 (5) :1377-1386 (2010)

• Background Reference 04:

  Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34 (5) :800-812 (2010)

• Other Product Names:

  S-adenosylmethionine synthase isoform type-1, AdoMet synthase 1, Methionine adenosyltransferase 1, MAT 1, Methionine adenosyltransferase I/III, MAT-I/III, MAT1A, AMS1, MATA1

• Tested Applications:

  WB, IHC-P

• Protein ID:

  417297

• Physical Properties:

  Liquid