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CA1 Antibody

CAT: 0223-56-562Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-562Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Variants of this gene have been described in some populations. Multiple alternatively spliced variants, encoding the same protein, have been identified. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature.
NCBI Gene ID
759
Swiss Prot
P00915
Accession Number
P00915
Host
Rabbit
Reactivity
Human
Immunogen
This CA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-90 amino acids from the N-terminal region of human CA1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
29 kDa
Fragment
Rabbit Ig
Symbol
CA1
NCBI Official Name
Carbonic anhydrase 1
NCBI Organism
Homo sapiens
Background Reference 01
Abhary, S., et al. Mol. Vis. 15, 1179-1184 (2009) :
Background Reference 02
Gambhir, K.K., et al. Biochem. Genet. 45 (5-6), 431-439 (2007) :
Background Reference 03
Temperini, C., et al. Bioorg. Med. Chem. Lett. 17 (8) :2210-2215 (2007)
Background Reference 04
Temperini, C., et al. Bioorg. Med. Chem. Lett. 16 (19) :5152-5156 (2006)
Other Product Names
Carbonic anhydrase 1, Carbonate dehydratase I, Carbonic anhydrase B, CAB, Carbonic anhydrase I, CA-I, CA1
Tested Applications
WB, IHC-P, Flow
Protein ID
115449
Physical Properties
Liquid

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