MRPS12 Antibody

CAT: 0223-56-556Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-556Size:400 µL
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Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4) . Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein.
NCBI Gene ID
6183
Swiss Prot
O15235
Accession Number
O15235
Host
Rabbit
Reactivity
Human
Immunogen
This MRPS12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-59 amino acids from the Central region of human MRPS12.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
15 kDa
Fragment
Rabbit Ig
Symbol
MRPS12
NCBI Official Name
28S ribosomal protein S12, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Zanotto, E., et al. Biochim. Biophys. Acta 1789 (5) :432-442 (2009)
Background Reference 02
Russo, A., et al. Biochim. Biophys. Acta 1779 (12) :820-829 (2008)
Background Reference 03
Stelzl, U., et al. Cell 122 (6) :957-968 (2005)
Background Reference 04
Cui, Y.P., et al. World J. Gastroenterol. 9 (9) :1892-1896 (2003)
Other Product Names
28S ribosomal protein S12, mitochondrial, MRP-S12, S12mt, MT-RPS12, MRPS12, RPMS12, RPSM12
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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