ABCD2 Antibody

• Background :

  The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.

• NCBI Gene ID :

  225

• Swiss Prot :

  Q9UBJ2

• Accession Number :

  Q9UBJ2

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This ABCD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-582 amino acids from the C-terminal region of human ABCD2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Obesity, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  83 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  ABCD2

• NCBI Official Name :

  ATP-binding cassette sub-family D member 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Matsukawa, T., et al. Neurogenetics (2010) In press :

• Background Reference 02 :

  Saito, A., et al. J. Hum. Genet. 54 (6) :317-323 (2009)

• Background Reference 03 :

  Maier, E.M., et al. Biochem. Biophys. Res. Commun. 377 (1) :176-180 (2008)

• Background Reference 04 :

  Lu, Y., et al. J. Lipid Res. 49 (12) :2582-2589 (2008)

• Other Product Names :

  ATP-binding cassette sub-family D member 2, Adrenoleukodystrophy-like 1, Adrenoleukodystrophy-related protein, hALDR, ABCD2, ALD1, ALDL1, ALDR, ALDRP

• Tested Applications :

  WB, IHC-P, Flow

• Protein ID :

  12643305

• Physical Properties :

  Liquid