MLPH Antibody

• Background:

  This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

• NCBI Gene ID:

  79083

• Swiss Prot:

  Q9BV36

• Accession Number:

  Q9BV36

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MLPH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 541-569 amino acids from the C-terminal region of human MLPH.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  66 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MLPH

• NCBI Official Name:

  Melanophilin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Park, J.W., et al. J. Med. Genet. 43 (7) :598-608 (2006)

• Background Reference 02:

  Seabra, M.C., et al. Traffic 5 (6) :393-399 (2004)

• Background Reference 03:

  Fukuda, M., et al. J. Cell. Sci. 117 (PT 4), 583-591 (2004) :

• Background Reference 04:

  Lukusa, T., et al. Genet. Couns. 15 (3) :293-301 (2004)

• Other Product Names:

  Melanophilin, Exophilin-3, Slp homolog lacking C2 domains a, SlaC2-a, Synaptotagmin-like protein 2a, MLPH, SLAC2A

• Tested Applications:

  WB, IHC-P

• Protein ID:

  32129730

• Physical Properties:

  Liquid