MLPH Antibody

• Background :

  This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

• NCBI Gene ID :

  79083

• Swiss Prot :

  Q9BV36

• Accession Number :

  Q9BV36

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This MLPH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 541-569 amino acids from the C-terminal region of human MLPH.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  66 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  MLPH

• NCBI Official Name :

  Melanophilin

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Park, J.W., et al. J. Med. Genet. 43 (7) :598-608 (2006)

• Background Reference 02 :

  Seabra, M.C., et al. Traffic 5 (6) :393-399 (2004)

• Background Reference 03 :

  Fukuda, M., et al. J. Cell. Sci. 117 (PT 4), 583-591 (2004) :

• Background Reference 04 :

  Lukusa, T., et al. Genet. Couns. 15 (3) :293-301 (2004)

• Other Product Names :

  Melanophilin, Exophilin-3, Slp homolog lacking C2 domains a, SlaC2-a, Synaptotagmin-like protein 2a, MLPH, SLAC2A

• Tested Applications :

  WB, IHC-P

• Protein ID :

  32129730

• Physical Properties :

  Liquid