PREX1 Antibody

• Background:

  The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs) . It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.

• NCBI Gene ID:

  57580

• Swiss Prot:

  Q8TCU6

• Accession Number:

  Q8TCU6

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PREX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1134-1163 amino acids from the C-terminal region of human PREX1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  186 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PREX1

• NCBI Official Name:

  Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lewis, J.P., et al. Genomics 96 (4) :211-219 (2010)

• Background Reference 02:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 03:

  Nie, B., et al. Cell. Signal. 22 (5) :770-782 (2010)

• Background Reference 04:

  Carretero-Ortega, J., et al. Mol. Pharmacol. 77 (3) :435-442 (2010)

• Other Product Names:

  Phosphatidylinositol 3,5-trisphosphate-dependent Rac exchanger 1 protein, P-Rex1, PtdIns (3,5) -dependent Rac exchanger 1, PREX1, KIAA1415

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  148886999

• Physical Properties:

  Liquid