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PREX1 Antibody

CAT: 0223-56-514Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-514Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs) . It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.
NCBI Gene ID
57580
Swiss Prot
Q8TCU6
Accession Number
Q8TCU6
Host
Rabbit
Reactivity
Human
Immunogen
This PREX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1134-1163 amino acids from the C-terminal region of human PREX1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
186 kDa
Fragment
Rabbit Ig
Symbol
PREX1
NCBI Official Name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
NCBI Organism
Homo sapiens
Background Reference 01
Lewis, J.P., et al. Genomics 96 (4) :211-219 (2010)
Background Reference 02
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 03
Nie, B., et al. Cell. Signal. 22 (5) :770-782 (2010)
Background Reference 04
Carretero-Ortega, J., et al. Mol. Pharmacol. 77 (3) :435-442 (2010)
Other Product Names
Phosphatidylinositol 3,5-trisphosphate-dependent Rac exchanger 1 protein, P-Rex1, PtdIns (3,5) -dependent Rac exchanger 1, PREX1, KIAA1415
Tested Applications
WB, IHC-P, Flow
Protein ID
148886999
Physical Properties
Liquid

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