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UBTF Antibody

CAT: 0223-56-496Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-496Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and multiple TBP-associated factors or 'TAFs') . Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988 [PubMed 3413483]) . UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990 [PubMed 2330041]) .
NCBI Gene ID
7343
Swiss Prot
P17480
Accession Number
P17480
Host
Rabbit
Reactivity
Human
Immunogen
This UBTF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 631-660 amino acids from the C-terminal region of human UBTF.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
89 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
UBTF
NCBI Official Name
Nucleolar transcription factor 1
NCBI Organism
Homo sapiens
Background Reference 01
Hisaoka, M., et al. Mol. Cell. Biol. 30 (20) :4952-4964 (2010)
Background Reference 02
Liu, Z., et al. Proteins 77 (2) :432-447 (2009)
Background Reference 03
Lin, C.I., et al. Biochem. Biophys. Res. Commun. 386 (2) :396-401 (2009)
Background Reference 04
Grob, A., et al. J. Cell. Sci. 122 (PT 4), 489-498 (2009) :
Other Product Names
Nucleolar transcription factor 1, Autoantigen NOR-90, Upstream-binding factor 1, UBF-1, UBTF, UBF, UBF1
Tested Applications
WB
Protein ID
136652
Physical Properties
Liquid

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A62373-100ULUBTF Antibody

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