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PSTPIP1 Antibody

CAT: 0223-56-465Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-465Size:400 µL
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Background
The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome.
NCBI Gene ID
9051
Swiss Prot
O43586
Accession Number
O43586
Host
Rabbit
Reactivity
Human
Immunogen
This PSTPIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-118 amino acids from the N-terminal region of human PSTPIP1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
48 kDa
Fragment
Rabbit Ig
Symbol
PSTPIP1
NCBI Official Name
Proline-serine-threonine phosphatase-interacting protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Andre, M.F., et al. Dig. Dis. Sci. 55 (6) :1681-1688 (2010)
Background Reference 02
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Background Reference 03
Hong, J.B., et al. J. Am. Acad. Dermatol. 61 (3) :533-535 (2009)
Background Reference 04
Voss, M., et al. BMC Immunol. 10, 53 (2009) :
Other Product Names
Proline-serine-threonine phosphatase-interacting protein 1, PEST phosphatase-interacting protein 1, CD2-binding protein 1, H-PIP, PSTPIP1, CD2BP1
Tested Applications
WB, Flow
Physical Properties
Liquid

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