PC Antibody

• Background :

  This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq].

• NCBI Gene ID :

  5091

• Swiss Prot :

  P11498

• Accession Number :

  P11498

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This PC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the N-terminal region of human PC.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Obesity, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine, Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  130 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  PC

• NCBI Official Name :

  Pyruvate carboxylase, mitochondrial

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  MacDonald, M.J., et al. Diabetologia 52 (6) :1087-1091 (2009)

• Background Reference 02 :

  Monnot, S., et al. Hum. Mutat. 30 (5) :734-740 (2009)

• Background Reference 03 :

  Wang, D., et al. Mol. Genet. Metab. 95 (1-2), 31-38 (2008) :

• Background Reference 04 :

  Vora, S., et al. Natl MedIndia 21 (3) :116-119 (2008)

• Other Product Names :

  Pyruvate carboxylase, mitochondrial, Pyruvic carboxylase, PCB, PC

• Tested Applications :

  WB, IHC-P

• Protein ID :

  1709947

• Physical Properties :

  Liquid