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PC Antibody

CAT: 0223-56-463Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-463Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq].
NCBI Gene ID
5091
Swiss Prot
P11498
Accession Number
P11498
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the N-terminal region of human PC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
130 kDa
Fragment
Rabbit Ig
Symbol
PC
NCBI Official Name
Pyruvate carboxylase, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
MacDonald, M.J., et al. Diabetologia 52 (6) :1087-1091 (2009)
Background Reference 02
Monnot, S., et al. Hum. Mutat. 30 (5) :734-740 (2009)
Background Reference 03
Wang, D., et al. Mol. Genet. Metab. 95 (1-2), 31-38 (2008) :
Background Reference 04
Vora, S., et al. Natl MedIndia 21 (3) :116-119 (2008)
Other Product Names
Pyruvate carboxylase, mitochondrial, Pyruvic carboxylase, PCB, PC
Tested Applications
WB, IHC-P
Protein ID
1709947
Physical Properties
Liquid

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