FASTK Antibody

• Background:

  The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.

• NCBI Gene ID:

  10922

• Swiss Prot:

  Q14296

• Accession Number:

  Q14296

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This FASTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-424 amino acids from the C-terminal region of human FASTK.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  61 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  FASTK

• NCBI Official Name:

  Fas-activated serine/threonine kinase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Simarro, M., et al. J. Immunol. 184 (9) :5325-5332 (2010)

• Background Reference 02:

  De Krom, M., et al. Biol. Psychiatry 65 (7) :625-630 (2009)

• Background Reference 03:

  Simarro, M., et al. Proc. Natl. Acad. Sci. U.S.A. 104 (27) :11370-11375 (2007)

• Background Reference 04:

  Wu, C., et al. Proteomics 7 (11) :1775-1785 (2007)

• Other Product Names:

  Fas-activated serine/threonine kinase, FAST kinase, FASTK

• Tested Applications:

  WB, IHC-P

• Protein ID:

  13124202

• Physical Properties:

  Liquid