RNH1 Antibody

• Background:

  Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]) . In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850) . Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.

• NCBI Gene ID:

  6050

• Swiss Prot:

  P13489

• Accession Number:

  P13489

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This RNH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 425-454 amino acids from the C-terminal region of human RNH1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  50 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  RNH1

• NCBI Official Name:

  Ribonuclease inhibitor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Martins-de-Souza, D., et al.Psychiatr Res 44 (14) :989-991 (2010)

• Background Reference 02:

  Martins-de-Souza, D., et al.Neural Transm 116 (3) :275-289 (2009)

• Background Reference 03:

  Turcotte, R.F., et al. Biochem. Biophys. Res. Commun. 377 (2) :512-514 (2008)

• Background Reference 04:

  Johnson, R.J., et al. Biochemistry 46 (45) :13131-13140 (2007)

• Other Product Names:

  Ribonuclease inhibitor, Placental ribonuclease inhibitor, Placental RNase inhibitor, Ribonuclease/angiogenin inhibitor 1, RAI, RNH1, PRI, RNH

• Tested Applications:

  WB, IF

• Protein ID:

  132573

• Physical Properties:

  Liquid