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RNH1 Antibody

CAT: 0223-56-428Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-428Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]) . In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850) . Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.
NCBI Gene ID
6050
Swiss Prot
P13489
Accession Number
P13489
Host
Rabbit
Reactivity
Human
Immunogen
This RNH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 425-454 amino acids from the C-terminal region of human RNH1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
50 kDa
Fragment
Rabbit Ig
Symbol
RNH1
NCBI Official Name
Ribonuclease inhibitor
NCBI Organism
Homo sapiens
Background Reference 01
Martins-de-Souza, D., et al.Psychiatr Res 44 (14) :989-991 (2010)
Background Reference 02
Martins-de-Souza, D., et al.Neural Transm 116 (3) :275-289 (2009)
Background Reference 03
Turcotte, R.F., et al. Biochem. Biophys. Res. Commun. 377 (2) :512-514 (2008)
Background Reference 04
Johnson, R.J., et al. Biochemistry 46 (45) :13131-13140 (2007)
Other Product Names
Ribonuclease inhibitor, Placental ribonuclease inhibitor, Placental RNase inhibitor, Ribonuclease/angiogenin inhibitor 1, RAI, RNH1, PRI, RNH
Tested Applications
WB, IF
Protein ID
132573
Physical Properties
Liquid

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