PITRM1 Antibody

• Background :

  ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.

• NCBI Gene ID :

  10531

• Swiss Prot :

  Q5JRX3

• Accession Number :

  Q5JRX3

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This PITRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 490-518 amino acids from the Central region of human PITRM1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  117 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  PITRM1

• NCBI Official Name :

  Presequence protease, mitochondrial

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Yoshida, T., et al. Int. J. Mol. Med. 25 (4) :649-656 (2010)

• Background Reference 02 :

  Pinho, C.M., et al. Neurosci. Lett. 469 (2) :204-208 (2010)

• Background Reference 03 :

  Oguri, M., et al. Am. J. Hypertens. 23 (1) :70-77 (2010)

• Background Reference 04 :

  Yoshida, T., et al. Int. J. Mol. Med. 24 (4) :539-547 (2009)

• Other Product Names :

  Presequence protease, mitochondrial, hPreP, 3424-, Pitrilysin metalloproteinase 1, Metalloprotease 1, hMP1, PITRM1, KIAA1104, MP1

• Tested Applications :

  WB

• Protein ID :

  485956568

• Physical Properties :

  Liquid