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PITRM1 Antibody

CAT: 0223-56-391Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-391Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.
NCBI Gene ID
10531
Swiss Prot
Q5JRX3
Accession Number
Q5JRX3
Host
Rabbit
Reactivity
Human
Immunogen
This PITRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 490-518 amino acids from the Central region of human PITRM1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
117 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PITRM1
NCBI Official Name
Presequence protease, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Yoshida, T., et al. Int. J. Mol. Med. 25 (4) :649-656 (2010)
Background Reference 02
Pinho, C.M., et al. Neurosci. Lett. 469 (2) :204-208 (2010)
Background Reference 03
Oguri, M., et al. Am. J. Hypertens. 23 (1) :70-77 (2010)
Background Reference 04
Yoshida, T., et al. Int. J. Mol. Med. 24 (4) :539-547 (2009)
Other Product Names
Presequence protease, mitochondrial, hPreP, 3424-, Pitrilysin metalloproteinase 1, Metalloprotease 1, hMP1, PITRM1, KIAA1104, MP1
Tested Applications
WB
Protein ID
485956568
Physical Properties
Liquid

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