IGSF8 Antibody

• Background:

  IGSF8 may play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.

• NCBI Gene ID:

  93185

• Swiss Prot:

  Q969P0

• Accession Number:

  Q969P0

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This IGSF8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-254 amino acids from the Central region of human IGSF8.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  65 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  IGSF8

• NCBI Official Name:

  Immunoglobulin superfamily member 8

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kolesnikova, T.V., et al. Neoplasia 11 (1) :77-86 (2009)

• Background Reference 02:

  Rocha-Perugini, V., et al. PLoS ONE (4), E1866 (2008) :

• Background Reference 03:

  Kettner, S., et al. Mol. Cell. Biol. 27 (21) :7718-7726 (2007)

• Background Reference 04:

  Sala-Valdes, M., et al. J. Biol. Chem. 281 (28) :19665-19675 (2006)

• Other Product Names:

  Immunoglobulin superfamily member 8, IgSF8, CD81 partner 3, Glu-Trp-Ile EWI motif-containing protein 2, EWI-2, Keratinocytes-associated transmembrane protein 4, KCT-4, LIR-D1, Prostaglandin regulatory-like protein, PGRL, CD316, IGSF8, CD81P3, EWI2, KCT4

• Tested Applications:

  WB, IHC-P

• Protein ID:

  74762642

• Physical Properties:

  Liquid