SLC12A6 Antibody

• Background:

  This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.

• NCBI Gene ID:

  9990

• Swiss Prot:

  Q9UHW9

• Accession Number:

  Q9UHW9

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SLC12A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the N-terminal region of human SLC12A6.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  128 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SLC12A6

• NCBI Official Name:

  Solute carrier family 12 member 6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rinehart, J., et al. Cell 138 (3) :525-536 (2009)

• Background Reference 02:

  Rudnik-Schoneborn, S., et al. Neuropediatrics 40 (3) :129-133 (2009)

• Background Reference 03:

  De Krom, M., et al. Biol. Psychiatry 65 (7) :625-630 (2009)

• Background Reference 04:

  Moser, D., et al. Neuropsychopharmacology 34 (2) :458-467 (2009)

• Other Product Names:

  Solute carrier family 12 member 6, Electroneutral potassium-chloride cotransporter 3, K-Cl cotransporter 3, SLC12A6, KCC3

• Tested Applications:

  WB, IHC-P

• Protein ID:

  27151690

• Physical Properties:

  Liquid