PIGA Antibody

• Background:

  This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12.

• NCBI Gene ID:

  5277

• Swiss Prot:

  P37287

• Accession Number:

  P37287

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PIGA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 455-484 amino acids from the C-terminal region of human PIGA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  54 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PIGA

• NCBI Official Name:

  Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Borowitz, M.J., et al. CytometryClin Cytom 78 (4) :211-230 (2010)

• Background Reference 02:

  Peruzzi, B., et al. Mutat. Res. 705 (1) :3-10 (2010)

• Background Reference 03:

  Araten, D.J., et al. Mutat. Res. 686 (1-2), 1-8 (2010) :

• Background Reference 04:

  Iida, Y., et al. Blood 83 (11) :3126-3131 (1994)

• Other Product Names:

  Phosphatidylinositol N-acetylglucosaminyltransferase subunit A, GlcNAc-PI synthesis protein, Phosphatidylinositol-glycan biosynthesis class A protein, PIG-A, PIGA

• Tested Applications:

  WB, IHC-P

• Protein ID:

  585696

• Physical Properties:

  Liquid