TGFB1 Antibody

• Background:

  TGFB1 is a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.

• NCBI Gene ID:

  7040

• Swiss Prot:

  P01137

• Accession Number:

  P01137

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This TGFB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-50 amino acids from the N-terminal region of human TGFB1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat, Pig, Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  44 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TGFB1

• NCBI Official Name:

  Transforming growth factor beta-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Perez, A.B., et al. Hum. Immunol. 71 (11) :1135-1140 (2010) Xu, Z., et al. Biochem. Biophys. Res. Commun. 401 (3) :376-381 (2010) Bran, G.M., et al. Anticancer Res. 30 (9) :3459-3463 (2010) Zauli, G., et al. Blood 80 (12) :3036-3043 (1992) Wrana, J.L., et al. Cell 71 (6) :1003-1014 (1992)

• Other Product Names:

  Transforming growth factor beta-1, TGF-beta-1, Latency-associated peptide, LAP, TGFB1, TGFB

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  135674

• Physical Properties:

  Liquid