TGFB2 Antibody

CAT: 0223-16-502Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-16-502Size:100 µL
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Background
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t (1;7) (q41; p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.
NCBI Gene ID
7042
Swiss Prot
P61812
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 20-160 of human TGFB2 (NP_001129071.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Cell Cycle, Growth Factors, Signal Transduction, Stem Cell
Purification
Affinity purification
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Fragment
IgG
Symbol
TGFB2
NCBI Official Name
Transforming growth factor, beta 2
NCBI Organism
Homo sapiens
Other Product Names
Transforming growth factor beta-2, BSC-1 cell growth inhibitor, TGF-beta-2, LDS4, TGF-beta2
Tested Applications
WB, IHC, IF
Physical Properties
Liquid

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