GNE Antibody

• Background :

  The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq].

• NCBI Gene ID :

  10020

• Swiss Prot :

  Q9Y223

• Accession Number :

  Q9Y223

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This GNE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-197 amino acids from the N-terminal region of human GNE.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Hamster, Mouse, Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  79 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  GNE

• NCBI Official Name :

  Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Stober, A., et al. Neuromuscul. Disord. 20 (5) :335-336 (2010)

• Background Reference 02 :

  Reinke, S.O., et al. Glycoconj. J. 26 (4) :415-422 (2009)

• Background Reference 03 :

  Tong, Y., et al. PLoS ONE (10), E7165 (2009) :

• Background Reference 04 :

  Reinke, S.O., et al. FEBS Lett. 581 (17) :3327-3331 (2007)

• Other Product Names :

  Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-GlcNAc-2-epimerase/ManAc kinase, UDP-N-acetylglucosamine 2-epimerase (hydrolyzing), UDP-GlcNAc-2-epimerase, Uridine diphosphate-N-acetylglucosamine-2-epimerase, N-acetylmannosamine kinase, ManAc kinase, GNE, GLCNE

• Tested Applications :

  WB, IHC-P

• Protein ID :

  45476991

• Physical Properties :

  Liquid