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AKR1C2 Antibody

CAT: 0223-56-299Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-299Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
NCBI Gene ID
1646
Swiss Prot
P52895
Accession Number
P52895
Host
Rabbit
Reactivity
Human
Immunogen
This AKR1C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-323 amino acids from the C-terminal region of human AKR1C2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
37 kDa
Fragment
Rabbit Ig
Symbol
AKR1C2
NCBI Official Name
Aldo-keto reductase family 1 member C2
NCBI Organism
Homo sapiens
Background Reference 01
Setlur, S.R., et al. Cancer Epidemiol. Biomarkers Prev. 19 (1) :229-239 (2010)
Background Reference 02
Wang, X., et al. PLoS ONE (8), E11934 (2010) :
Background Reference 03
Reding, K.W., et al. Am. J. Epidemiol. 170 (10) :1241-1249 (2009)
Background Reference 04
Cogliati, C., et al. FEBS J. 276 (20) :6011-6023 (2009)
Other Product Names
Aldo-keto reductase family 1 member C2, 1---, 3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase 2, DD-2, DD2, Dihydrodiol dehydrogenase/bile acid-binding protein, DD/BABP, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Type III 3-alpha-hydroxysteroid dehydrogenase, AKR1C2, DDH2
Tested Applications
WB, IHC-P
Protein ID
20532374
Physical Properties
Liquid

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