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PSCD2 Antibody

CAT: 0223-56-293Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-293Size:400 µL
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Background
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
9266
Swiss Prot
Q99418
Accession Number
Q99418
Host
Rabbit
Reactivity
Mouse
Immunogen
This PSCD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the N-terminal region of human PSCD2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
47 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CYTH2
NCBI Official Name
Cytohesin-2
NCBI Organism
Homo sapiens
Background Reference 01
Merkulova, M., et al. Biochim. Biophys. Acta 1797 (8) :1398-1409 (2010)
Background Reference 02
Torii, T., et al. J. Biol. Chem. 285 (31) :24270-24281 (2010)
Background Reference 03
White, D.T., et al. Mol. Biol. Cell 21 (4) :562-571 (2010)
Background Reference 04
Bouschet, T., et al. J. Cell. Sci. 120 (PT 15), 2489-2497 (2007) :
Other Product Names
Cytohesin-2, ARF exchange factor, ARF nucleotide-binding site opener, Protein ARNO, PH, SEC7 and coiled-coil domain-containing protein 2, CYTH2, ARNO, PSCD2, PSCD2L
Tested Applications
WB
Protein ID
13124707
Physical Properties
Liquid

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