RPGR Antibody

• Background:

  This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP) . Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined.

• NCBI Gene ID:

  6103

• Swiss Prot:

  Q92834

• Accession Number:

  Q92834

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This RPGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 744-772 amino acids from the C-terminal region of human RPGR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  113 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  RPGR

• NCBI Official Name:

  X-linked retinitis pigmentosa GTPase regulator

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Clark, G.R., et al. Ophthalmology 117 (11) :2169-2177 (2010)

• Background Reference 02:

  Schmid, F., et al. Invest. Ophthalmol. Vis. Sci. 51 (3) :1628-1635 (2010)

• Background Reference 03:

  Ji, Y., et al. Curr. Eye Res. 35 (1) :73-79 (2010)

• Background Reference 04:

  Sheng, X., et al. Mol. Vis. 16, 1620-1628 (2010) :

• Other Product Names:

  X-linked retinitis pigmentosa GTPase regulator, RPGR, RP3, XLRP3

• Tested Applications:

  WB, IHC-P

• Protein ID:

  23503098

• Physical Properties:

  Liquid