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RPGR Antibody

CAT: 0223-56-288Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-288Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP) . Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined.
NCBI Gene ID
6103
Swiss Prot
Q92834
Accession Number
Q92834
Host
Rabbit
Reactivity
Human
Immunogen
This RPGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 744-772 amino acids from the C-terminal region of human RPGR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
113 kDa
Fragment
Rabbit Ig
Symbol
RPGR
NCBI Official Name
X-linked retinitis pigmentosa GTPase regulator
NCBI Organism
Homo sapiens
Background Reference 01
Clark, G.R., et al. Ophthalmology 117 (11) :2169-2177 (2010)
Background Reference 02
Schmid, F., et al. Invest. Ophthalmol. Vis. Sci. 51 (3) :1628-1635 (2010)
Background Reference 03
Ji, Y., et al. Curr. Eye Res. 35 (1) :73-79 (2010)
Background Reference 04
Sheng, X., et al. Mol. Vis. 16, 1620-1628 (2010) :
Other Product Names
X-linked retinitis pigmentosa GTPase regulator, RPGR, RP3, XLRP3
Tested Applications
WB, IHC-P
Protein ID
23503098
Physical Properties
Liquid

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