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TOR2A Antibody

CAT: 0223-56-260Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-260Size:400 µL
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Background
Salusins are multifunctional bioactive peptides discovered by bioinformatics analyses of a full-length cDNA library. Salusin alpha and salusin beta are related peptides of 28 and 20 amino acids that were recently characterized. These peptides are considered to be biosynthesized from preprosalusin, an alternative-splicing product of the torsion dystonia-related gene (TOR2A), after frameshift reading and digestion at dibasic amino acids. Salusin alpha has recently been shown to be involved in atherosclerosis; it potently suppresses acyl-CoA:cholesterol acyltransferase-1 which stores cholesterol ester converted from free cholesterol in macrophages, thereby reducing human macrophage foam cell formation.
NCBI Gene ID
27433
Swiss Prot
Q5JU69
Accession Number
Q5JU69
Host
Rabbit
Reactivity
Human
Immunogen
This TOR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-221 amino acids from the Central region of human TOR2A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
36 kDa
Fragment
Rabbit Ig
Symbol
TOR2A
NCBI Official Name
Torsin-2A
NCBI Organism
Homo sapiens
Background Reference 01
O'Farrell, C.A., et al. Neurobiology 164 (3) :1127-1137 (2009)
Background Reference 02
Sato, K., et al. Peptides 29 (12) :2203-2207 (2008)
Background Reference 03
Watanabe, T., et al. Hypertens. Res. 31 (3) :463-468 (2008)
Background Reference 04
Wang, Z., et al. Eur. J. Pharmacol. 539 (3) :145-150 (2006)
Other Product Names
Torsin-2A, Torsin family 2 member A, Torsin-related protein 1, TOR2A, TORP1
Tested Applications
WB, IHC-P
Protein ID
74742272
Physical Properties
Liquid

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