TOR2A Antibody

• Background :

  Salusins are multifunctional bioactive peptides discovered by bioinformatics analyses of a full-length cDNA library. Salusin alpha and salusin beta are related peptides of 28 and 20 amino acids that were recently characterized. These peptides are considered to be biosynthesized from preprosalusin, an alternative-splicing product of the torsion dystonia-related gene (TOR2A), after frameshift reading and digestion at dibasic amino acids. Salusin alpha has recently been shown to be involved in atherosclerosis; it potently suppresses acyl-CoA:cholesterol acyltransferase-1 which stores cholesterol ester converted from free cholesterol in macrophages, thereby reducing human macrophage foam cell formation.

• NCBI Gene ID :

  27433

• Swiss Prot :

  Q5JU69

• Accession Number :

  Q5JU69

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This TOR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-221 amino acids from the Central region of human TOR2A.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  36 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  TOR2A

• NCBI Official Name :

  Torsin-2A

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  O'Farrell, C.A., et al. Neurobiology 164 (3) :1127-1137 (2009)

• Background Reference 02 :

  Sato, K., et al. Peptides 29 (12) :2203-2207 (2008)

• Background Reference 03 :

  Watanabe, T., et al. Hypertens. Res. 31 (3) :463-468 (2008)

• Background Reference 04 :

  Wang, Z., et al. Eur. J. Pharmacol. 539 (3) :145-150 (2006)

• Other Product Names :

  Torsin-2A, Torsin family 2 member A, Torsin-related protein 1, TOR2A, TORP1

• Tested Applications :

  WB, IHC-P

• Protein ID :

  74742272

• Physical Properties :

  Liquid