CYBA Antibody

• Background:

  Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta) . This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.

• NCBI Gene ID:

  1535

• Swiss Prot:

  P13498

• Accession Number:

  P13498

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CYBA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117-145 amino acids from the C-terminal region of human CYBA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology, Obesity

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  21 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CYBA

• NCBI Official Name:

  Cytochrome b-245 light chain

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Katakami, N., et al. Atherosclerosis 212 (2) :534-538 (2010)

• Background Reference 03:

  Tu, Y.C., et al. Acta Pharmacol. Sin. 31 (7) :874-880 (2010)

• Background Reference 04:

  Moreno, M.U., et al. Drug News Perspect. 23 (5) :316-324 (2010)

• Other Product Names:

  Cytochrome b-245 light chain, Cytochrome b (558) alpha chain, Cytochrome b558 subunit alpha, Neutrophil cytochrome b 22 kDa polypeptide, Superoxide-generating NADPH oxidase light chain subunit, p22 phagocyte B-cytochrome, p22-phox, p22phox, CYBA

• Tested Applications:

  WB, IF

• Protein ID:

  311033459

• Physical Properties:

  Liquid