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Neutrophil elastase Antibody

CAT: 0223-56-220Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-220Size:400 µL
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Background
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN) . This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
NCBI Gene ID
1991
Swiss Prot
P08246
Accession Number
P08246
Host
Rabbit
Reactivity
Human
Immunogen
This Neutrophil elastase antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-39 amino acids from the N-terminal region of human Neutrophil elastase.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
29 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ELANE
NCBI Official Name
Neutrophil elastase
NCBI Organism
Homo sapiens
Background Reference 01
Kallquist, L., et al. Exp. Cell Res. 316 (19) :3182-3196 (2010)
Background Reference 02
Rabai, G., et al. Thromb. Res. 126 (2), E94-E101 (2010) :
Background Reference 03
Newburger, P.E., et al. Pediatr Blood Cancer 55 (2) :314-317 (2010)
Background Reference 04
Hayashi, M., et al.Nippon Med Sch 77 (2) :80-85 (2010)
Other Product Names
Neutrophil elastase, Bone marrow serine protease, Elastase-2, Human leukocyte elastase, HLE, Medullasin, PMN elastase, ELANE, ELA2
Tested Applications
WB
Protein ID
119292
Physical Properties
Liquid

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