MDK Antibody

• Background:

  Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angiogenesis (summary by Reynolds et al., 2004 [PubMed 15197188]) .

• NCBI Gene ID:

  4192

• Swiss Prot:

  P21741

• Accession Number:

  P21741

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This MDK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-143 amino acids from the C-terminal region of human MDK.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  16 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MDK

• NCBI Official Name:

  Midkine

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ferreira, R.C., et al. Nat. Genet. 42 (9) :777-780 (2010) Kerzerho, J., et al. J. Immunol. 185 (1) :418-423 (2010) Yao, X., et al. Acta Pharmacol. Sin. 31 (5) :629-637 (2010) Zhang, Z.H., et al. Cell Prolif. 43 (2) :184-194 (2010) Rice, G.E., et al. J. Exp. Clin. Cancer Res. 29, 62 (2010) :

• Other Product Names:

  Midkine, MK, Amphiregulin-associated protein, ARAP, Midgestation and kidney protein, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein, MDK, MK1, NEGF2

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  127116

• Physical Properties:

  Liquid