TRIM72 Antibody

• Background:

  TRIM72 is a muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca (2+) -dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity) .

• NCBI Gene ID:

  493829

• Swiss Prot:

  Q6ZMU5

• Accession Number:

  Q6ZMU5

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  This TRIM72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-327 amino acids from the C-terminal region of human TRIM72.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  53 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TRIM72

• NCBI Official Name:

  Tripartite motif-containing protein 72

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Park, E.Y., et al. Proteins 78 (3) :790-795 (2010)

• Background Reference 02:

  Han, S., et al. Hum. Mol. Genet. 18 (6) :1171-1180 (2009)

• Background Reference 03:

  Martin, J., et al. Nature 432 (7020) :988-994 (2004)

• Other Product Names:

  HGNC:32671

• Tested Applications:

  WB, IHC-P

• Protein ID:

  126253816

• Physical Properties:

  Liquid