TRADD Antibody

• Background:

  The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq].

• NCBI Gene ID:

  8717

• Swiss Prot:

  Q15628

• Accession Number:

  Q15628

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TRADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-151 amino acids from the Central region of human TRADD.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  34 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TRADD

• NCBI Official Name:

  Tumor necrosis factor receptor type 1-associated DEATH domain protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Pointon, J.J., et al. Ann. Rheum. Dis. 69 (6) :1243-1246 (2010)

• Background Reference 02:

  Hosgood, H.D. III, et al. Occup Environ Med 66 (12) :848-853 (2009)

• Background Reference 03:

  Yerges, L.M., et al. J. Bone Miner. Res. 24 (12) :2039-2049 (2009)

• Background Reference 04:

  Liang, X.S., et al. Br. J. Haematol. 146 (4) :418-423 (2009)

• Other Product Names:

  Tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain, TRADD

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  6094511

• Physical Properties:

  Liquid