DDIT3 Antibody

• Background:

  This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

• NCBI Gene ID:

  1649

• Swiss Prot:

  P35638

• Accession Number:

  P35638

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This DDIT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the C-terminal region of human DDIT3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Hamster, Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  19 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  DDIT3

• NCBI Official Name:

  DNA damage-inducible transcript 3 protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Park, S.H., et al. J. Immunol. 185 (9) :5522-5530 (2010)

• Background Reference 02:

  Goodall, J.C., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (41) :17698-17703 (2010)

• Background Reference 03:

  Zhang, H.M., et al. J. Virol. 84 (17) :8446-8459 (2010)

• Background Reference 04:

  Cazanave, S.C., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (1), G236-G243 (2010) :

• Other Product Names:

  DNA damage-inducible transcript 3 protein, DDIT-3, C/EBP zeta, C/EBP-homologous protein, CHOP, C/EBP-homologous protein 10, CHOP-10, CCAAT/enhancer-binding protein homologous protein, Growth arrest and DNA damage-inducible protein GADD153, DDIT3, CHOP, CHOP10, GADD153

• Tested Applications:

  WB, IF, Flow

• Protein ID:

  544022

• Physical Properties:

  Liquid