TGFBR2 Antibody

• Background:

  This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

• NCBI Gene ID:

  7048

• Swiss Prot:

  P37173

• Accession Number:

  P37173

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This TGFBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-40 amino acids from the N-terminal region of human TGFBR2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  65 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TGFBR2

• NCBI Official Name:

  TGF-beta receptor type-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Inamoto, S., et al. Cardiovasc. Res. 88 (3) :520-529 (2010)

• Background Reference 02:

  Bianchini, G., et al. J. Clin. Oncol. 28 (28) :4316-4323 (2010)

• Background Reference 03:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 04:

  Kim, J.N., et al. Toxicology 275 (1-3), 29-35 (2010) :

• Other Product Names:

  TGF-beta receptor type-2, TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II, TGFBR2

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  116242818

• Physical Properties:

  Liquid