PAX5 Antibody

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t (9;14) (p13; q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

5079

Q02548

Q02548

Human

This PAX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 178-207 amino acids from the Central region of human PAX5.

Unconjugated

Primary Antibodies

Neuroscience

This antibody is purified through a protein A column, followed by peptide affinity purification.

Batch dependent

Predicted species reactivity based on immunogen sequence: Mouse

Supplied in PBS with 0.09% (W/V) sodium azide.

None

Blue Ice

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

42 kDa

Rabbit Ig

PAX5

Paired box protein Pax-5

Homo sapiens

Song, J., et al. Arch. Pathol. Lab. Med. 134 (11) :1702-1705 (2010)

Okamoto, R., et al. Haematologica 95 (9) :1481-1488 (2010)

Best, A., et al. Leuk. Res. 34 (8) :1098-1102 (2010)

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Paired box protein Pax-5, B-cell-specific transcription factor, BSAP, PAX5

WB, IHC-P, Flow

417449