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MLH1 Antibody

CAT: 0223-55-988Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-988Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.
NCBI Gene ID
4292
Swiss Prot
P40692
Accession Number
P40692
Host
Rabbit
Reactivity
Human
Immunogen
This MLH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 452-480 amino acids from the Central region of human MLH1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
85 kDa
Fragment
Rabbit Ig
Symbol
MLH1
NCBI Official Name
DNA mismatch repair protein Mlh1
NCBI Organism
Homo sapiens
Background Reference 01
Ling, Z.Q., et al. Cancer Lett. 297 (2) :244-251 (2010)
Background Reference 02
Qi, Y., et al. J. Biol. Chem. 285 (43) :33010-33017 (2010)
Background Reference 03
Borras, E., et al. Cancer Res. 70 (19) :7379-7391 (2010)
Background Reference 04
Mangoni, M., et al. Int. J. Radiat. Oncol. Biol. Phys. (2010) In press :
Other Product Names
DNA mismatch repair protein Mlh1, MutL protein homolog 1, MLH1, COCA2
Tested Applications
WB, Flow
Protein ID
730028
Physical Properties
Liquid

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