HRAS Antibody

CAT: 0223-55-979Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-55-979Size:400 µL
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Background
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
NCBI Gene ID
3265
Swiss Prot
P01112
Accession Number
P01112
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This HRAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-176 amino acids from the C-terminal region of human HRAS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
21 kDa
Fragment
Rabbit Ig
Symbol
HRAS
NCBI Official Name
GTPase HRas
NCBI Organism
Homo sapiens
Background Reference 01
Ma, Z., et al. Oncogene 29 (41) :5559-5567 (2010)
Background Reference 02
Van Engen-van Grunsven, A.C., et al. Am. J. Surg. Pathol. 34 (10) :1436-1441 (2010)
Background Reference 03
Li, H., et al. Oncogene 29 (36) :5083-5094 (2010)
Background Reference 04
Kwack, K.B., et al. KoreanGastroenterol 56 (2) :78-82 (2010)
Other Product Names
GTPase HRas, H-Ras-1, Ha-Ras, Transforming protein p21, c-H-ras, p21ras, GTPase HRas, N-terminally processed, HRAS, HRAS1
Tested Applications
WB, IF
Protein ID
131869
Physical Properties
Liquid

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